Process for preparing high purity ursodeoxycholic acid
CA 1185233 A · Owner: Erregierre S.P.A. · Inventors: Molinari, Egidio; Bonaldi, Antonio
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A b s t r a c t :, A process for preparing very pure ursodeoxycholic acid starting from cholic acid (I) by:, a) selectively oxidising it to 3 alpha 12 alpha-dihydroxy-, -7-ketocholanic acid (II) b) reducing acid (II) to 3 alpha, 7 beta 12 alpha-trihydroxy, cholanic acid (III) c) oxidising a 3,7-ester of acid (III) to 3 alpha 7 beta-, -dihydroxy-12-keto-5-beta-cholanic acid (IV) by treatment with hypochlorite followed by hydrolysis d) preparing the tris-trimethylsilyl derivative of acid (IV) e) eliminating the trimethylsilyl groups f) reducing the very pure acid (IV) by the Wolff-Kishner method to ursodeoxycholic acid. alternatively the Wolff-Kishner method can be applied directly to the …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted April 9, 1985. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended April 9, 2002.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.