RECOVERY OF L-PHENYLALANINE AND L-ASPARTIC ACID DURING PREPARATION OF .alpha.-L-ASPARTYL-L-PHENYLALANINE METHYL ESTER

Abstract From the Canadian patent

There is described an improved process for the separation and recovery of L-phenylalanine and L-aspartic acid from sidestreams resulting from the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester. It has been found that superior separation is obtained by combining one or more of the mother liquor and wash solutions formed during the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrolyzing, same to afford the hydrohalide salts of L-aspartic acid and L-phenylalanine, acidifying the hydrolysis solution to precipitate the hydrohalide salt of L-phenylalanine separating the hydrohalide salt of L-phenylalanine dissolving it in water and adjusting the pH of the …