D-phenylalanyl-l-propyl-l-arginine aldehyde sulfate and process for the preparation thereof

Abstract From the Canadian patent

The invention relates to D-phenylalanyl-L- -prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative containing an acid-sensitive protecting group at its amino terminal,wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts end the resulting free tripeptide aldehyde sulfate is isolated, The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.