Detection of chemical mutagens in marker rescue assay
CA 1180649 A · Owner: Mount Sinai School Of Medicine Of The City University Of New York · Inventors: Phillips, Robert A.; Garro, Anthony J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present application discloses a short-term microbial assay useful in detecting chemical mutagens. A Bacillus subtilis which is infected with a strain of the temperate bacteriophage ?105 having a conditional lethal mutation is specifically illustrated. In the assay exogenous DNA from wild-type ?105 is reacted with a potential mutagen and then transfected into the B. subtilis carrying a mutated ?105 DNA. After plating an increase in the frequency of clear plaques signifies that the test compund is mutagenic. The present invention provides a short-term mutagenicity test which detects frameshift as well as base substitution mutations induced by chemicals.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted January 8, 1985. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended January 8, 2002.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.