Process for making histamine antagonists
CA 1138453 A · Owner: Smith Kline & French Laboratories Limited · Inventors: Brown, Thomas H.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
2-Aminopyrimidones which are histamine H2-antagonists having the structure, in which Het is a nitrogen-containing 5- or 6- membered fully unsaturated heterocyclic group, m is 0 or 1 Y is, methylene, oxygen or sulphur, n is 2 or 3 Z is hydrogen, or lower alkyl, A is an alkylene group or an alkylene group interrupted by oxygen or sulphur and B is hydrogen, or a methyl, cycloalkyl heteroaryl, phenyl, naphthyl, benzodioxolyl or dihydrobenzodioxinyl group are prepared by a process in which an amine Het-(CH2)mY(CH2)nNH2 is reacted with a 2-nitroaminopyrimidone of structure, The new 2-nitroaminopyrimidone intermediates are prepared by reacting nitroguanidine with an oxoester RO2CCH(COZ)-A-B where …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted December 28, 1982. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended December 28, 1999.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.