Process for the preparation of ¬1-3-mercapto-(2s)- methylpropionyl -pyrrolidine-(2s)-carboxylic acid
CA 1137499 A · Owner: Egyt Gyogyszervegyeszeti Gyar · Inventors: Bakonyi, Anna; Fazekas, Gabor; Rozsa, Laszlo
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to a novel process for the preparation of 1-3-mercapto-/2S/-methylpropionyl-pyrrolidine-/2S/-carboxylic acid through the N-acylation of L-proline. According to the process of the invention L-proline is acylated with a 3-halogen-2-methylpropionyl chloride of the formula III, III, wherein Hal is a halogen atom preferably chlorine or bromine, the obtained 1-3-halogen-/2S/-methylpropionyl-pyrrolidine-/2S/-carboxylic acid wherein, Hal is as stated above, is reacted with an alkali thiosulfate or alkali trithiocarbonate and the reaction product is hydrolized with an acid. The process of the invention is very economical as compared with the known processes. The desired product …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted December 14, 1982. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended December 14, 1999.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.