Alkylthioalkyl-isoxanzoles and -isoxazolines

Abstract From the Canadian patent

Abstract of the Disclosure Compounds of the formula 1, 1, in which the dotted line represents an optional double bond, R1 is lower alkyl, COOH, COO(lower alkyl), CONH2, CON(lower alkyl)2, CN, CH2OH CH2OSO2(lower alkyl), CH2O(lower alkyl) or, CH2S(lower alkyl), R2 is H, H2, or lower alkyl R3, is H or S(lower alkyl), R4 and R5 are the same or different and each is H, lower alkyl, S(lower alkyl) COOH, or COO(lower alkyl), and the sulfoxides and sulfones of the above compounds as well as their pharmaceutically acceptable salts. The compounds possess anti-inflammatory, analgesic, and anti-pyretic properties, and methods for their preparation and use are also disclosed.