4-n-acylfortimicin b derivatives and the chemical conversion of fortimicin b to fortimicin a

Abstract From the Canadian patent

This invention provides 4-N-acylfortimicin B derivatives of the structure, wherein R is acyl aminoacyl, N-momoloweralkylaminoacyl, N,N-dilowaralkylaminoacyl hydroxy-substituted aminoacyl, or substituted aminoacyl of the formula -?-CH2NHR1, where R1 is an acyl radical derived from an amino acid or a short peptide, and the pharmaceutically acceptable salts thereof. The compounds are useful as intermediates for preparing 4-N-alkyl or substituted alkylfortimicin B derivatives. In addition to their utility as intermediates some of the compounds of this invention are also useful as antimicrobial agents. -1-