Anti-inflammatory 1-substituted-4,5-diaryl-2- (substituted-thio) imidazoles and their corresponding sulfoxides and sulfones

Abstract From the Canadian patent

Anti-inflammatory 1-substituted-4,5-diaryl-2-(substitutedthio) imidazoles and their corresponding sulfoxides and sulfones useful for treating arthritis and related disease are disclosed. The imidazoles are of the formula - R1, where n = 0, 1, or 2; R1 = C1 - C6 alkyl; allyl: vinyl; -CH2COCH3; -CH2S(O)mCH3, where m = 0, 1 or 2; mono- and poly-, halo- C1 - C4 alkyl; R2 and R3 the same or different =, Y1 and Y2, the same or different = hydrogen C1 - C4 alkoxy, C1 - C4 alkyl, Cl, F, CF3 NH2, -N(CH3)2, NO2, CH3S-, CH3SO2-, or Y1 and Y2 taken together forming a dioxymethylene bridge; provided, when R1 = C1 - C4 alkyl, C3 - C4 haloalkyl with halogen substituted at the 3 or 4 position allyl, or …