4-hydroxy-1,2-benzisothiazole and their manufacture

Abstract From the Canadian patent

The present invention relates to 1,2-benzisothiazoles of the general formula (I) :, (I), where R1 is hydrogen amino, which is unsubstituted or sub-, stituted by the acyl radical of an organic acid of 1 to 4 carbon atoms, or nitro, and where the phenolic hydroxyl may or may not be etherified by benzyl or esterified by the radical of an organic acid of 1 to 4 carbon atoms. The invention more particularly relates to 4-hydroxy-1,2-benzisothiazole and its derivatives, and their process of preparation. These products are intermediates for new drugs which are useful in cardiac and circulatory disorders.