Penicillin compounds and process for preparation thereof

Abstract From the Canadian patent

A penicillin compound of the formula wherein R is a formyl or acetyl group, and a nontoxic pharmaceutically acceptable salt thereof. The penicillin compound is prepared by (A) reacting a compound of the formula, or its salt or its reactive derivative at the carboxyl group with 6-.alpha.-, amino-p-hydroxybenzylpenicillin or its salt or its derivative or reacting, a compound of the formula or its salt or its reactive derivative at the carboxyl group with 6-amino-, penicillanic acid or its salt or its derivative (b) optionally hydrolyzing, or catalytically hydrogenolyzing the reaction product and (e) optionally, converting the reaction product to a nontoxic pharmaceutically acceptable salt. …