Process for preparing ergoline derivatives

Abstract From the Canadian patent

This invention relates to a new process for preparing new ergoline derivatives of the general formula (I) (I), wherein R1 is hydrogen or methoxy; R2 is hydrogen or methyl; and, X is hydroxy R3COO, S-R4 or NR5R6 in which R3 is a, straight or branched alkyl having from 1 to 6 carbon atoms unsubstituted- or substituted-phenyl, the substituents being selected from the class consisting of chlorine bromine, alkyl, or alkoxy having from 1 to 4 carbon atoms cycloalkyl containing, from 3 to 6 carbon atoms or a heterocycle;, R4 is phenyl or a heterocycle and, R5 and R6 are alkyl having from 1 to 4 carbon atoms or, together with the n atom to which they are attached forming a, heterocycle. The …