Amino-spiro¬oxa(or thia) cycloalkane-penam - carboxylic acid derivatives

Abstract From the Canadian patent

Amino-spiro oxa(or thia)cycloalkane penam -carboxylic acid derivatives having the formula wherein X is a sulfur or oxygen atom or the sulfinyl group n is 1 or 2, m is 1 or 2, R1 is hydrogen R2 is one of, the radicals known in the chemistry of the penicillins preferably 2-phenylacetyl , 2-amino-2-phenylacetyl 5-methyl-, 3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl or, R1 and R2 together represent a bivalent radical R3 prefer-, ably (hexahydro-1H-azepin-1-yl)methylene and their therapeutically acceptable non-toxic salts and process for preparing the same. These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases …