Psychopharmacologically active peptides and peptide derivatives, and the use thereof

Abstract From the Canadian patent

Biologically active novel peptides and peptide-derivatives of the general formula:, I, where A represents H-(L or D)Met H-(L or D)Met(?O), H-(L or D)Met(?O2), desamino-Met desamino-Met(?O), desamino-Met(?O2) or the group H2N-B-CO-; B represents a branched or straight-chain alkylene (C1-C6) or alkylidene (C1-C6) group; Q represents the amino-acid residue -NH-CHR-CO-; R represents alkyl (C1-C6), p-hydroxyphenylmethyl 3-indolylmethyl or phenylmethyl;, R1 and R2 represent hydrogen or an alkyl(1-6C) group and, Z represents N-(phenylalkyl)amino N-(.beta.-indolylalkyl)amino, L-Trp-OH L-Phe-OH, L-Trp-Gly-OH or L-Phe-Gly-OH as well as the functional derivatives thereof. They are useful for their …