Topical pharmaceutical compositions for treating anomalous mobilization and deposition of bone mineral in humans and other animals

Abstract From the Canadian patent

Compositions for topical application to the epidermis at an afflicted situs for the treatment of anomalous mobilization and deposition of calcium phosphate salts in the tissues of humans and other animals are disclosed. The compositions comprise: (i) from about 0.5% to about 20 of a pharmaceutically acceptable organophosphonate compound; and (ii) a carrier which comprises from about 0.1% to about 15% of the composition of an organosulfoxide compound wherein said organosulfoxide compound is a dialkylsulfoxide of the formula R'R"SO wherein group R' is a C6-C20 alkyl or substituted alkyl group and wherein group R" is a Cl-C3 alkyl or substituted alkyl group the balance, of said carrier …