Hydroxymethyl-pyridine esters and a process for the preparation thereof

Abstract From the Canadian patent

New hydroxymethyl-pyridine esters of the general formula, (I), wherein R represents a 9-xanthenyl group or a phenyl group substituted by a halogen atom or a trifluoromethyl group or by an alkyl or alkoxy group both having 1 to 4 carbon atoms, and pharmaceutically acceptable acid addition salts and quaternary salts thereof are prepared by acylating the corresponding hydroxymethyl pyridines with a carboxylic acid of the general formula R-COOH, wherein R has the same meaning as above, or with a reactive derivative thereof and, if desired, converting the obtained product of the general formula I into a pharmaceutically acceptable acid addition salt or quaternary salt thereof. The new compounds …