Enzymatic preparation of prostacyclin and its salts

Abstract From the Canadian patent

Compounds of the formula (I) ( I ), ( wherein R is hydrogen or a pharmacologically acceptable cation ) may be prepared by incubating microsomes from mammalian tissue with a prostaglandin endoperoxide. The compound of formula ( I ) wherein R is hydrogen is identified as prostacyclin. The compounds of formula ( I ) are novel and exhibit a variety of pharmacological properties including blood platelet anti-aggregatory activity vasodilatory activity, wound-healing activity and reduction of gastric secretion. The said anti-aggregatory activity of the compounds is particularly potent. The compounds of formula ( I ) may be incorporated into pharmaceutical compositions for human or veterinary …