Process for the production of 1,1-dithien-(3)-yl-1- hydroxy-(3)propyl-1-phenyl-1-hydroxy-(2)- propyl-amine and 1,1-dithien-(3)-yl-(1)-propen- (3)-yl-1-phenyl-(2)-propyl-amine

Abstract From the Canadian patent

The present invention provides a process for the production of 1,1-dithien-(3)-yl-1-hydroxy-(3)-propyl-1phenyl-1-hydroxy-(2)-propyl-amine, which comprises condensing thien-(3)-yl lithium with a .beta.-halogen propionic acid alkyl ester corresponding to the formula, II in which R is a lower saturated aliphatic alkyl group and Hal is chlorine, bromine or iodine, in an inert medium at a temperature below -50°C, after which the resulting compound corresponding to the formula, III, in which Hal is chlorine bromine or iodine, is reacted with, 2-amino-1-hydroxy-1-phenylpropane in an inert medium in the presence of a basic compound.