Alkyne compounds and process for their preparation

Abstract From the Canadian patent

Alkyne compounds of the formula wherein R1 is alkyl of up to 4 carbon atoms or phenyl R2 is H or alkanoyl, of up to 6 carbon atoms A is monohalophenyl or dihalophenyl wherein halo is F, C1 or Br and n is 0 or 1; and physiologically acceptable metal salts thereof have anit-inflammatory activity. These compounds can be made by treating compounds of the formula wherein Q is a functionally modified hydroxyl group and R1 A and n are, as above, with a solvolyzing agent. When R2 is to be alkanoyl the thus-, produced alkyne compound wherein R2 is hydrogen is thereafter treated with an acylating agent in order to produce a corresponding compound wherein R2 is alkanoyl of up to 6 carbon atoms.