Allergen-polymer conjugates as immunologically specific suppressants

Abstract From the Canadian patent

Allergen-containing substances methods of preparing the, same and using the same as immunologically specific suppressants of the production of reaginic antibodies directed to the allergen in question are disclosed. The allergen-containing substances are according to the invention characterized as covalent conjugates of the allergen molecules with non-immunogenic water-soluble polymers. The degree of conjugation is such that the conjugates are rendered tolerogenic as well as substantially non-allergenic and non-immunogenic. The new conjugates are useful for immunologically specific suppression of common allergies in mammals including, humans, which are mediated by reaginic antibodies of the …