Substituted 2-phenylamino-imidazolines-(2), their acid addition salts, pharmaceuticals comprising same and processes for their production

Abstract From the Canadian patent

This invention relates to novel derivatives of 2-phenylamino-imidazoline-(2) having the formula I I, wherein R1, R2 and R3, which may be the same or different each represents a hydrogen, fluorine, chlorine or bromine atom or a methyl, ethyl, methoxy, hydroxy, trifluoromethyl or cyano group; and R4 represents a group of the formula (in which n is an integer from 2 to 5). These compounds have interesting pharmacological properties. In particular the, novel compounds exhibit analgesic and bradycardiac activities and may therefore be useful in the treatment of pain and/or coronary disease. Processes for the preparation of the novel compounds are described and exemplified and examples of, …