O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions comprising the same

Abstract From the Canadian patent

This invention relates to compounds of the general formula I and pharmaceutically acceptable salts thereof (I), wherein R2 hydrogen or alkyl having one to five carbon atoms; R3 is alkyl having one to five carbon atoms, cycloalkyl or phenyl optionally substituted with hydroxyl or phenyl; or R2 and R3 together form a five- to eight-membered ring optionally containing also other heteroatoms and/or fused with an other ring; R4 is cycloalkyl aromatic or heteroaromatic group, optionally substituted with one or more halogens alkoxy or alkyl and/or, fused with an other ring preferably phenyl, naphthyl, quinolyl, isoquinolyl pyridyl, pyrazolyl; R5 is hydrogen or alkyl having one to four carbon atom …