Substituted ureido-compounds

Abstract From the Canadian patent

Described herein are novel hydroxylpolyhaloisopropylsubstituted ureido compounds exhibiting useful antihypertensive activity, processes for their preparation and pharmaceutical compositions containing these compounds. The ureido-compounds are selected from phenyl ureas, oxazolines and quinazolines represented by the formula:, and the pharmaceutically acceptable salts of the oxazolines and quinazolines, where Z represents , or, together with X2, the grouping, in which R1 is ethylene or substituted ethylene and R and R2 represent other specified substituents and wherein one of X2 and X4 is the hydroxypolyhaloisopropyl grouping , in which Y independently represents hydrogen chlorine or …