Process for the conversion of 6-aminopenicillanic acid (6-apa) in 7-aminodesacetoxycephalosporanic acid (7-adca)
CA 1056816 A · Owner: Gema S.A. · Inventors: Palomo Coll, Antonio L.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a process for the conversion of 6-aminopenicillanic acid (6-APA) to 7-aminodesacetoxycephalosporanic acid (7-ACDA) the, improvement comprises reacting one mole of a compound selected from the group consisting of alpha-chloro- and alpha-bromobenzyl penicillin-(s)-sulphoxide with from two to four moles of 3-trimethylsilyl-2-oxazolidinone (TMSO) at a temperature of between 60° and 120°C in an inert non-hydroxylic solvent and in the presence of thiourea and a compound selected from the group consisting of triethylamine, dimethylaniline, quinoline and picoline p-toluene sulfonate to obtain a solution thereafter, removing the solvent by evaporation diluting the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Granted June 19, 1979. A Canadian patent filed before October 1, 1989 lasted 17 years from grant, so its term ended June 19, 1996.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.