Alkyl and heterothio derivatives of alkyl o or s carbonyl thioacetyl cephalosporins

Abstract From the Canadian patent

This invention relates to new three-thio derivatives of thioalkoxycarbonyl-and carbamoyl-substituted thioacetylcephalosporins of the formula, wherein R is hydrogen lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl a salt forming ion, or the group, -CH2-O-?-R4 and in addition tri(lower alkyl)stannyl and, phenyl when R? is lower alkylthio; R1 is hydrogen lower, alkyl, phenyl, thienyl, furyl or pyridyl; R? is lower alkylthio, lower alkylamino or phenyl-lower alkylamino; R3 is lower alkylthio or a 5-membered heterocycle containing only nitrogen and carbon or nitrogen, carbon and sulfur in the ring when R? is lower alkylthio, and when R? is lower alkylamino or phenyl-lower alkylamino, R3 is …