Method of preparation of insoluble biologically active compounds

Abstract From the Canadian patent

This invention relates to a method of preparation of insoluble biologically active insoluble compounds. This method consists in oxidizing a polymer carrier containing a side chain p-phenylenediamine skeleton which, polymer is of the general formula I I, where R1 is a polymer residue, R2 is a low alkyl group and x, is an integer ranging from 1 to 4 in the presence of a, soluble biologically active compound containing a primary amino group selected in the group consisting of enzymes coenzymes, inhibitors of enzymes, hormones and antigens. Such insoluble biologically active compounds can particularly be used in affinity chromatography.