Isoquinoline derivatives and process for the production thereof

Abstract From the Canadian patent

Novel isoquinoline derivatives of the formula wherein R1 and R2 collectively are a C-N bond or R1 is H and R2 is H or R8 wherein R8 is alkanoyl of 1-10 carbon atoms benzoyl, methoxybenzoyl, alkyl of 1-4 carbon atoms or the, corresponding alkyl substituted by phenyl OH, ArCOO-, ArCOHN-, piperidino, 3,4-dehydropiperidino morpholino, carboxy, carbomethoxy or carbethoxy R3 is H, methyl or, ethyl, R4 and R5 each are H or collectively a C-C bond; R6 and R7 each are H or methoxy, and Ar is 3,4,5-trimethoxyphenyl, and the physiologically acceptable acid addition salts and quaternary ammonium salts thereof have cardiovascular activity and can be prepared by acylating a corresponding primary amine …